Residential: Default exposure doses for chronic exposure in drinking water and cancer risk estimates

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Screenshot of a table showing residential default exposure doses for chronic exposure to 1,2,3-TRICHLOROPROPANE

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Residential: Default exposure doses for chronic exposure to 1,2,3-TRICHLOROPROPANE in drinking water at 0.00015 mg/L along with cancer risk estimates

Air Example for PHAGM Screening Analysis
Exposure Group
CTE Dose (mg/kg/day)
CTE Cancer Risk
CTE Exposure Duration for Cancer (yrs)
RME Dose (mg/kg/day)
RME Cancer Risk
RME Exposure Duration for Cancer (yrs)

Birth to < 1 year

 9.7E-6 – 1 2.1E-5 – 1

1 to < 2 years

 4.1E-6 – 1 1.2E-5 – 1

2 to < 6 years

 3.2E-6 – 4 8.4E-6 – 4

6 to < 11 years

 2.4E-6 – 5 6.6E-6 – 5

11 to < 16 years

 1.7E-6 – 1 5.2E-6 – 5

16 to < 21 years

 1.6E-6 – 0 5.1E-6 – 5

Total Child

 – 8.4E-5 ‡ 12 – 2.4E-4 ‡ 21

Adult

 2.3E-6 1.1E-5 ‡ 12 5.8E-6 7.4E-5 ‡ 33

Pregnant Women

 1.8E-6 – – 5.3E-6 – –

Lactating Women

 3.4E-6 – – 7.4E-6 – –

Birth to < 21 years plus 12 years during adulthood §

 – – – – 2.7E-4 ‡ 33

Source: Bosage Drinking Water Sampling Data, 2019

Abbreviations: CTE = central tendency exposure (typical); mg/kg/day = milligram chemical per kilogram body weight per day; mg/L = milligram chemical per liter water; RME = reasonable maximum exposure (higher); yrs = years

* The calculations in this table were generated using ATSDR’s PHAST. The cancer risks were calculated using the cancer slope factor of 30 (mg/kg/day)-1 and age-dependent adjustment factors.

‡ A shaded cell indicates that the cancer risk exceeds one extra case in a million people similarly exposed, which ATSDR evaluates further.

§This cancer risk represents a scenario where children are likely to continue to live in their childhood home as adults.