In-Depth Toxicological Effects Analysis

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This section provides guidance on how to perform an in-depth toxicological effects analysis. This is the process ATSDR uses to examine human exposure to a contaminant to determine if the exposure may cause health problems.

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CDC; photographer: Debora Cartagena

In-Depth Toxicological Effects Analysis and E-Manual Section Overview
Identify Data from Studies Used to Develop Non-Cancer Health Guidelines
Review the Original Journal Article(s) that Served as the Basis for the Non-Cancer Health Guidelines, If Warranted
Examine More Recent Non-Cancer Studies, If Warranted
Evaluate the Evidence to Examine Non-Cancer Effects
Evaluate the Evidence to Examine Cancer Effects
Review Tox Data for Other Health Effects with Doses or Air Concentrations Similar to Those for Your Site
Review Other Contaminant-Specific Toxicological Information
Examine Radiation Exposures
Evaluate Site-Specific Health Effects Data
Key Resources
Key Resources
ATSDR’s Document Repository
ATSDR’s Toxic Substances Portal
EPA’s CompTox Chemistry Dashboard
EPA’s Integrated Risk Information System (IRIS) database
ATSDR PHAT, Tox Mini-Module (in Module 7)

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Refer to ATSDR’s Public Health Assessment Training (PHAT) course. ATSDR’s Tox Evaluation Mini-Module, part of Module 7, will help you learn more about toxicological effects evaluations, see case study examples, and perform case exercises.

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MODULE 7: Health Effects Evaluation

ATSDR Toxicological Profiles

Consult ATSDR Toxicological Profiles for information on the available toxicological and epidemiological information on a substance.

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Public Health Assessment Site Tool

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ATSDR’s Public Health Assessment Site Tool (PHAST) is a multi-purpose resource that ATSDR recommends health assessors use when preforming the PHA process. Use the PHAST CVs & Health Guidelines Module to find toxicological data on contaminants at your sites. Health assessors and those involved in the PHA process can gain access by contacting phast@cdc.gov.