Toxicological Profile for Perfluoroalkyls (PFAS)
Title: Toxicological Profile for Perfluoroalkyls
Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.
Type of Dissemination: HISA
Timing of Review (including deferrals): November 2014 and August 2017
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in 2015. A draft of the revised profile will be made available for public comment in 2018.
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | MD, MS |
|---|---|
| Current Position Title | Professor, Director of Academic Programs in Occupational Medicine |
| Organizational Affiliation(s) | Center of Excellence in Environmental Toxicology University of PennsylvaniaPhiladelphia, Pennsylvania 19104 |
| Areas of Expertise, Discipline, Relevant Experiences | occupational and environmental skin diseases, ultraviolet radiation effects on skin and eyes, the toxicity of polyaromatic hydrocarbons, PCBs, organometals, monomers used in plastics and resins, and other subjects. He is a recipient of the Kehoe Award of Merit from the American College of Occupational and Environmental Medicine. |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | Department of Environmental Medicine University of Rochester School of Medicine |
| Areas of Expertise, Discipline, Relevant Experiences | the relationships between brain neurotransmitter systems and children’s neurodevelopment, and how such relationships are altered by exposures to environmental toxicants, including the role played by environmental neurotoxicant exposures in developmental disabilities and neurodegenerative diseases. |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor Emeritus |
| Organizational Affiliation(s) | College of Pharmacy Ohio State University Columbus, Ohio |
| Areas of Expertise, Discipline, Relevant Experiences | pharmacokinetics, particularly the construction and validation of mathematical models that describe or explain the kinetics of complex biological systems; interspecies scaling of pharmacokinetic model parameter values and xenobiotic metabolism |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Associate Professor |
| Organizational Affiliation(s) | Department of Pharmacology & Toxicology Brody School of Medicine East Carolina University |
| Areas of Expertise, Discipline, Relevant Experiences | Environmental and neural science, environmental toxicology, immunotoxicology. Her environmental developmental neuroimmunotoxicology research program explores relationships between biological organisms and their developmental responses after exposure to environmental toxicants. Special emphasis research on early life exposure to a variety of agents that may affect the immune, nervous, and endocrine systems, resulting in altered development such as disease or disorder in childhood or later in life. Her expertise lies in how impacts on the immune system lead to downstream effects on the nervous system. She has numerous publications and research in the area of PFAS. |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor of Epidemiology |
| Organizational Affiliation(s) | Brown University School of Public Health, with a joint appointment in Obstetrics and Gynecology in the Alpert Medical School, Providence, RI |
| Areas of Expertise, Discipline, Relevant Experiences | Environmental hazards in the workplace and community, reproductive health outcomes, and environmental influences on cancer. He has done extensive work on health effects of nonionizing radiation, pesticides, drinking water treatment by-products, and perfluorinated compounds. He has directed 30 doctoral dissertations and 15 master’s theses; authored nearly 350 papers in professional journals and editor or author of three books. He has served as editor at the American Journal of Environmental hazards in the workplace and community, reproductive health outcomes, and environmental influences on cancer. He has done extensive work on health effects of nonionizing radiation, pesticides, drinking water treatment by-products, and perfluorinated compounds. He has directed 30 doctoral dissertations and 15 master’s theses; authored nearly 350 papers in professional journals and editor or author of three books. He has served as editor at the American Journal of Epidemiology and as a member of the Epidemiology and Disease Control-1 study section of the National Institutes of Health and currently is an editor at Epidemiology. He was President of the Society for Epidemiologic Research and the Society for Pediatric and Perinatal Epidemiologic Research and North American Regional Councilor for the International Epidemiological Association. Dr. Savitz is a member of the National Academy of Sciences Institute of Medicine. From 2013-2017 he served as Vice President for Research at Brown University. |
| Recommended by Scientific/Professional Society or General Public |
No |
CDC/ATSDR’s Response to Reviewers’ Comments: 2014 Tox profile Perfluoroalkyls Formal Disposition pdf icon[PDF – 664 KB]
Perfluoroalkyls Responses to peer reviewer comments 2018 Tox profile pdf icon[PDF – 1 MB]
The ISI/HISA Dissemination Itself
The 2018 ISI/HISA Dissemination Itselfexternal icon
Additional elements for the 2018 update to be added to the public posting as they become available