Toxicological Profile for Mirex and Chlordecone
Title: Toxicological Profile for Mirex and Chlordecone
Subject of Planned Report: Mirex and chlordecone are two separate synthetic insecticides that have similar chemical structures. Animal stidies show that mirex can be taken into the bloodstream when one breathes in cigarette smoke containing mirex or eats food contaminated with mirex. Animal studies have shown that eating mirex can cause harmful effects on the stomach, intestines, liver, kidneys, eyes, thyroid, nervous system, and reproductive system.The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.
Type of Dissemination: ISI
Timing of Review (including deferrals): April 2018
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Senior Scientist Emeritus |
| Organizational Affiliation(s) | Lovelace Respiratory Research Institute |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: toxicology, biochemistry, chemistry
Experience: Served on Special Study Sections of the National Institutes of Health and the Health Effects Institute to review grant proposals in the area of lung biochemistry. Developed in vivo screening tests for pulmonary toxicants based on analysis of bronchoalveolar washings for biomarkers of lung injury and repair. Research on the mechanisms by which pulmonary inflammation leads to repair or to chronic disease (fibrosis, emphysema). Research on the pharmacokinetics of inhaled xenobiotics (particularly vapors) and chemical-specific biomarkers of chemical exposure. |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | PharmD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: experimental pharmacology, neurotoxicology
Experience: Director, Neurotoxicology Research Core, NIEHS Center in Ecogenetics and Environmental Health, University of Washington. University of Washington Core faculty in Interdisciplinary Molecular and Cellular Biology Program, Environmental and Occupational Epidemiology Training Program, Environmental Pathology/Toxicology Training Program (Director of Neurotoxicology and Developmental Toxicology Core). |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | MD, Ph.D. |
|---|---|
| Current Position Title | Research Director |
| Organizational Affiliation(s) | Inserm U1085 – IRSET, Research Institute of Occupational and Environmental Health |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: epidemiology, reproduction, fertility, prostate cancer, hormone dependent cancers, prenatal and post-natal development, endocrine disruptors
Experience: Head of the Guadeloupe Site of Inserm U1085 – IRSET. Head of the Team: “Exposure Assessment And Epidemiological Research on Environment, Reproduction, and Development (3ERD),” Inserm U1085 – IRSET, Rennes, France. |
| Recommended by Scientific/Professional Society or General Public |
No |
Charge to Peer Reviewers: Charge to Peer Reviewers Mirex and Chlordecone
Peer Reviewers’ Comments and CDC/ATSDR’s Response to Reviewers’ Comments:
The ISI/HISA Dissemination Itself:
https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=1190&tid=276