Toxicological Profile for Hexachlorobutadiene
Title: Toxicological Profile for Hexachlorobutadiene
Subject of Planned Report: Environmental Protection Agency has determined that hexachlorobutadiene is a possible human carcinogen. Kidney, brain, and liver damage were also seen in rabbits after skin contact. Ingestion of hexachlorobutadiene damaged the kidneys of rats and mice and the liver of rats. Studies in mice showed that brief exposure to high concentrations of hexachlorobutadiene irritate the nose. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.
Type of Dissemination: ISI
Timing of Review (including deferrals): June July 2018
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in 2019
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | PhD, MSc |
|---|---|
| Current Position Title | Director, UCLA Industrial Hygiene Program |
| Organizational Affiliation(s) | Department of Environmental Health Sciences, Fielding School of Public Health, UCLA |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: physical chemistry, chemical engineering, industrial hygiene
Experience: Professor, Step V, Department of Environmental Health Sciences, School of Public Health, UCLA Center for Occupational and Environmental Health, University of California at Los Angeles; Distinguished Professor, National Taiwan University, School of Public Health, Institute of Environmental Health; Director, UCLA Industrial Hygiene Program, Department of Environmental Health Sciences, Fielding School of Public Health. Research areas of interest: Detection and quantitative analysis of organic and inorganic pollutants and carcinogens in industrial and agricultural industries, and in the environment at the ng and pg level; Development of sensitive personal monitoring methods in industry, and workplace protection factors; Direct reading instruments, and direct-indicating sensors; Detection and quantitation of toxins in biological tissues which cause cancer or produce unwanted biological effects; Liquid chromatography-mass spectroscopy; Gas chromatography-mass spectroscopy; Developmental analytical chemistry dealing with organic, inorganic and organometallic species in-vivo and in-vitro; Photodecomposition and photosensitization; Chemiluminescent and bioluminescent analysis; Multielemental analyses and receptor analyses; Biological monitoring -screening and specific tests; Hazardous Waste -field and laboratory methods; Inductively coupled plasma-mass spectrometry and atomic emission spectroscopy; Organometallic biological compounds. |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor Emeritus of Pharmacology and Toxicology |
| Organizational Affiliation(s) | College of Pharmacy, University of Georgia |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: pharmacology, toxicology
Experience: Extensive experience as a peer reviewer for CDC, ATSDR, NIOSH, and EPA. Research interests include basic questions which impact toxicity risk assessments and experimental research on the use of physiologically-based pharmacokinetic (PBPK) models to predict the administered dose/exposure level anticipated to produce the effect in humans. |
| Recommended by Scientific/Professional Society or General Public |
No |
| Academic and Professional Credentials | PhD, MS |
|---|---|
| Current Position Title | Associate Professor |
| Organizational Affiliation(s) | Institute of Environmental Engineering, National Sun Yet-sen University |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: civil and environmental engineering
Experience: Associate director, Aerosol Science Research Center, National Sun Yat-sen University, Kaohsiung，Taiwan. Director of Environmental Protection and Safety, Environmental Protection and Safety Center, National Sun Yat-sen University, Kaohsiung, Taiwan, Associate Editor, Journal of Ecology & Natural Resources. Associate Member (A.M.), American Society of Civil Engineers. Member, American Chemical Society. Engineer-In-Training (EIT).Board for Professional Engineers and Land Surveyors, California, Certificate No. EIT 128709. |
| Recommended by Scientific/Professional Society or General Public |
No |
Charge to Peer Reviewers: Charge to Peer Reviewers Hexachlorobutadiene
Additional elements to be added to the public posting as they become available