Toxicological Profile for Ethylene Oxide
Title: Toxicological Profile for Ethylene Oxide
Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances to support of public health assessment efforts.
Type of Dissemination: ISI
Timing of Review (including deferrals): 1/22/2020; 12/26/2021 (inhalation MRL update)
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment in 2020.
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 7
Primary Disciplines or Expertise: Toxicology, Toxicological pathology, Epidemiology, Environmental Health, Chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | MD, PhD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | Veterinary Integrative Biosciences College of Vet Medicine & Biomedical Sciences Texas A&M University |
| Areas of Expertise, Discipline, Relevant Experiences | Pharmacology; toxicology; risk assessment methods for carcinogens; hepatic toxicity; DNA damage and repair; mutagenesis; carcinogenesis; mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | Professor, Department of Environmental Health Professor, Department of Epidemiology Rollins School of Public Health Emory University |
| Areas of Expertise, Discipline, Relevant Experiences | Statistical modeling; environmental health; epidemiology; pesticides in relation to neurodegenerative diseases; adult lead exposure and cancer; PFOA and a variety of diseases |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | |
|---|---|
| Current Position Title | Group Lead, Ambient Aire Monitor Group |
| Organizational Affiliation(s) | Office of Air Quality Planning & Standards U.S. Environmental Protection Agency |
| Areas of Expertise, Discipline, Relevant Experiences | EPA expert on EPA national ambient air monitoring networks for multiple pollutants; particular expertise on ethylene oxide air levels. Eight publications from 2005-2019, cited by 428 other papers. Expertise crucial for review of 5.3.1 Potential for Human Exposure: Releases to The Environment: Air (air monitoring measurements & methods) to ensure that information is complete and accurate |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor Emeritus |
| Organizational Affiliation(s) | Environmental Health Sciences, Lawrence Berkeley National Laboratory, UC Berkeley School of Public Health |
| Areas of Expertise, Discipline, Relevant Experiences | Risk assessment; model uncertainty and reliability in exposure/risk assessment; environmental and occupational radioactivity; mass transfer at environmental and human/environment boundaries |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Director, Analytical Chemistry & Pharmaceutics |
| Organizational Affiliation(s) | RTI International Research Triangle Park North Carolina, USA |
| Areas of Expertise, Discipline, Relevant Experiences | Biomarkers, exposure assessment, pharmacokinetics, nanotoxicology, biochemistry |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Associate Professor |
| Organizational Affiliation(s) | Pathobiology and Diagnostic Investigation College of Veterinary Medicine; Michigan State University |
| Areas of Expertise, Discipline, Relevant Experiences | Pathophysiology and pharmacology; toxicology; mechanisms of airway injury and systemic responses induced by inhalation exposures to pathogens, toxicants, and environmental pollutants; role of diet and metabolic susceptibility in adverse cardiopulmonary responses to air pollutant exposure; nanomaterials |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | University of Cincinnati |
| Areas of Expertise, Discipline, Relevant Experiences | Pathology; toxicology |
| Recommended by Scientific/Professional Society or General Public | No |
Additional elements to be added to the public posting as they become available:
CDC/ATSDR’s Response to Reviewers’ Comments [PDF – 594 KB]
Charge to Peer Reviewers (Inhalation MRL Update) [PDF – 170 KB]
CDC/ATSDR’s Response to Reviewers’ Comments (Inhalation MRL Update) [PDF – 231 KB]