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Appendix D: Agenda For The Expert Panel Meeting

Historical Document

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Expert Panel on Health Effects of Asbestos
and Synthetic Vitreous Fibers (SVF):
The Influence of Fiber Length

Agenda

Day #1, Tuesday, October 29, 2002 (afternoon only)

1:00 PM

Registration

 

1:30 PM

Welcome and Introductory Remarks

Dr. Henry Falk
Assistant Administrator, ATSDR

1:45 PM

Purpose of Meeting

RADM Robert C. Williams
Director, Division of Health Assessment and Consultation, ATSDR

2:00 PM

Review of meeting charge and agenda

Moton Lippman, Ph. D
Panel Chair

2:15 PM

Introduction of panelists

Panelists

2:25 PM

Meeting Logistics

ERG
Topic #1: Physiological Fate of Asbestos and SVF less than 5 Microns in Length
2:30 PM

What happens to small fibers when inhaled?
Discussion Leaders: Dr. Lippman and Dr. Oberdorster

  • Depostional Patterns in The Lung
  • Clearance
  • Biopersistence
  • Migration from the lung
  • Fiber-like vs. particle-like activity patterns
  • Asbestos vs. MMV
   
3:30 PM

Break

  
3:45 PM Topic #1 (continued)  
5:30 PM Observer comments/questions  
6:00 PM Adjourn  
Day #2, Wednesday, October 30, 2002
8:00 AM Review of Day #1 issues Morton Lippmann, Ph. D
Panel Chair
Topic #2: Health Effects of Asbestos and SVF less than 5 Microns in Length
8:15 AM

What do human/epidemiological data tell us about small fibers?
Discussion Leaders: Dr. Lockey and Dr. Case

  • Cancer effects
  • Non-cancer effects
  • Irritant effects
  • Association between fiber length and fiber-like toxicity
  • Thresholds of toxic action
  • Asbestos vs. MMVF
  
9:45 AM   Break
10:00 AM  

How do animal/experimental data augment our understanding of human health effects?
Discussion Leaders: Dr. McConnell and Dr. Case

  • Cancer effects
  • Non-cancer effects
  • Irritant effects
  • Association between fiber length and fiber-like toxicity
  • Thresholds of toxic action
  • Asbestos vs. MMVF
12:00 PM   Lunch
1:00 PM  

What are the mechanisms of action of small fibers?
Can the more robust knowledge base about other fiber or particle materials
supplement this understanding?
Discussion Leaders: Dr. Mossman and Dr. Wallace

  • Immune system responses
  • Cell signaling
  • Role of reactive oxygen/nitrogen species
  • Function of growth factors
  • Other mechanisms
  • Asbestos vs. MMVF
3:30 PM Break  
Topic #3: Data Gaps
3:45 PM Data gaps and research needs Panelists
4:30 PM Observer comments/questions  
5:00 PM Conclusions/recomendations Panelists
5:30 PM Adjourn  

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