Uranium

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of uranium.

Details

Title: Toxicological Profile for Uranium

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): February 2011

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for Public Comment (how and when): A draft will be made available for public comment in April 2011.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3 or fewer

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Charge to Peer Reviewers: DTEM Charge to Peer Reviewers

Reviewers

Academic and Professional Credentials
  • Ph.D., Comparative Pathology, University of California- Davis
  • D.V.M., Veterinary Medicine, Washington State University
  • B.S., Biological Sciences, Washington State University
Current Position Title
Scientist Emeritus
Organizational Affiliation(s)
Lovelace Respiratory Research Institute, Albuquerque, NM
Areas of Expertise, Discipline, Relevant Experiences
Dr. Hahn has extensive expertise in:

  • Radiation
  • Inhalation exposures
  • Animal models
  • Depleted uranium
  • Pulmonary toxicology
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
  • Ph.D., Statistics, Cornell University
  • M.S., Statistics, Cornell University
  • B.A., Mathematics, Colgate University
Current Position Title
Chair, Graduate Interdisciplinary Program in Statistics
Organizational Affiliation(s)
University of Arizona, Tucson, AZ
Areas of Expertise, Discipline, Relevant Experiences
Dr. Piegorsch is a statistician with extensive experience analyzing environmental health data and application of benchmark dose modeling. He has knowledge of:

  • Uranium and uranium compounds’ physical and chemical properties
  • Toxicokinetics
  • Key health end points
  • Mechanisms of action
  • Quantification of risk to humans
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
  • Ph.D., Human Anatomy and Cell Biology, University of Western Ontario
  • M.S., Zoology, State University of New York
  • B.S., Mathematics, State University of New York
Current Position Title
Professor, Histology
Organizational Affiliation(s)
Mercer University School of Medicine
Areas of Expertise, Discipline, Relevant Experiences
Dr. Zalups has expertise in the area of cellular and molecular biology and the toxicology of heavy metals such as uranium. Much of his work focuses on the mechanisms by which select environmental toxicants affect the kidneys.
Recommended by Scientific/Professional
Society or General Public
No