N-nitrosodi-n-propylamine

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of N-nitrosodi-n-propylamine.

Details

Title: Toxicological Profile for N-nitrosodi-n-propylamine

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft will be made available for public comment in 2019

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
PhD
Current Position Title
Toxicologist, Professor Emeritus, Pharmacology and Toxicology, Washington State University
Organizational Affiliation(s)
MoBull Consulting and Washington State University
Richland, WA
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Pharmacology
  • Toxicology
  • Chemistry
  • Water pollution
Experience:
Dr. Bull is a former:
  • Toxicologist / research pharmacologist at the US EPA Health Effects Research Laboratory
  • Chief for the Toxicological Assessment branch at US EPA
  • Director, Toxicology and Microbiology Division, EPA
He was Professor and then Chair, Pharmacology/ Toxicology Program at Washington State University before becoming a Senior Staff Scientist at Battelle Pacific Northwest Laboratory. He has numerous awards, has been invited speaker and authors to close to a hundred publications.
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor of Biochemistry, Tadashi Inagami Chair in Biochemistry Professor
Organizational Affiliation(s)
Department of Biochemistry
The Vanderbilt University School of Medicine
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Biochemistry
  • Drug metabolism
  • Mass spectrometry
  • Mutation
  • Pharmacology
  • Polymorphism
  • Spectroscopy
  • Toxicology
  • Chemistry
  • Enzymology of bioactivation and detoxication of foreign compounds
Experience:

  • Mechanisms of activation and detoxication of chemical carcinogens and toxicants
  • Characterization of enzymes involved in these processes
  • Metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor of Pharmacology & Toxicology
Organizational Affiliation(s)
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health
  • Volatile organic chemicals (VOCs) and pesticides: low environmental exposures and cancer risk to humans; drug-chemical interactions
  • Physiologically based pharmacokinetic models, pyrethroid pesticides and children’s health.

Experience:

Dr. Bruckner is an environmental toxicologist whose research areas include:

  • Development of in vitro testing systems for hepatorenal toxins
  • Comparison of the relative pharmacokinetics and toxicity of inhaled and ingested organics
  • Investigation of the toxicity of halogenated hydrocarbons
Dr. Bruckner has served as consultant to state and federal agencies and to industry. He has also served as a member of expert panels for these groups. He serves on editorial boards of the Journal of Toxicology and Environmental Health, Toxicology, and Toxicology and Applied Pharmacology.
Recommended by Scientific/Professional
Society or General Public
No

Resources

Additional elements to be added to the public posting as they become available:

Peer Review Charge for N-nitrosodi-n-propylamine
Review the peer review charge and post-public draft of n-nitrosodi-n-propylamine.
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Content Source:
Agency for Toxic Substances and Disease Registry