Mirex and Chlordecone

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of mirex and chlordecone.

Details

Title: Toxicological Profile for Mirex and Chlordecone

Subject of Planned Report: Mirex and chlordecone are two separate synthetic insecticides that have similar chemical structures. Animal studies show that mirex can be taken into the bloodstream when one breathes in cigarette smoke containing mirex. It can also get into the blood stream when one eats food contaminated with mirex. Animal studies have shown that eating mirex can cause harmful effects on the:

  • Stomach
  • Intestines
  • Liver
  • Kidneys
  • Eyes
  • Thyroid
  • Nervous system
  • Reproductive system.

The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
PhD
Current Position Title
Senior Scientist Emeritus
Organizational Affiliation(s)
Lovelace Respiratory Research Institute
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Toxicology
  • Biochemistry
  • Chemistry
Experience:
  • Served on Special Study Sections of the National Institutes of Health and the Health Effects Institute to review grant proposals in the area of lung biochemistry
  • Developed in vivo screening tests for pulmonary toxicants based on analysis of bronchoalveolar washings for biomarkers of lung injury and repair
  • Research on the mechanisms by which pulmonary inflammation leads to repair or to chronic disease (fibrosis, emphysema)
  • Research on the pharmacokinetics of inhaled xenobiotics (particularly vapors) and chemical-specific biomarkers of chemical exposure
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PharmD
Current Position Title
Professor
Organizational Affiliation(s)
Department of Environmental and Occupational, Health Sciences, School of Public Health, University of Washington
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
Experimental pharmacology and neurotoxicology

Experience:
Director, Neurotoxicology Research Core, NIEHS Center in Ecogenetics and Environmental Health, University of Washington

University of Washington Core faculty in:
  • Interdisciplinary Molecular and Cellular Biology Program
  • Environmental and Occupational Epidemiology Training Program
  • Environmental Pathology/Toxicology Training Program (Director of Neurotoxicology and Developmental Toxicology Core)
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
MDPh.D.
Current Position Title
Research Director
Organizational Affiliation(s)
Inserm U1085 – IRSET, Research Institute of Occupational and Environmental Health
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Epidemiology
  • Reproduction
  • Fertility
  • Prostate cancer
  • Hormone dependent cancers
  • Prenatal and post-natal development
  • Endocrine disruptors
Experience:
Head of the Guadeloupe Site of Inserm U1085 – IRSET. Head of the Team: “Exposure Assessment And Epidemiological Research on Environment, Reproduction, and Development (3ERD),” Inserm U1085 – IRSET, Rennes, France.
Recommended by Scientific/Professional
Society or General Public
No

Resources

Peer Review Charge for Mirex and Chlordecone
Review the peer review charge and post-public draft of mirex and chlordecone.
CDC/ATSDR’s Response to Reviewers’ Comments for Toxicological Profile for Mirex and Chlordecone
Download
Download
The ISI/HISA Dissemination Itself
Print
Content Source:
Agency for Toxic Substances and Disease Registry