At a glance
NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of lead.
Details
Title: Toxicological Profile for Lead
Subject of Planned Report: The main target for lead toxicity is the nervous system. Lead exposure may also cause:
- Weakness in fingers, wrists, or ankles
- Small increases in blood pressure
- Anemia
- Brain and kidney damage
- Death
- Miscarriage
- Damaged sperm production
The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.
Type of Dissemination: ISI
Timing of Review (including deferrals): February 2018
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public Comment (how and when): A draft was made available for public comment June 2019
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
Reviewers
Academic and Professional Credentials
PhD
Current Position Title
Full Professor of Toxicology Area – Faculty of Chemistry
Organizational Affiliation(s)
University of the Republic of Uruguay
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
- Chemistry
- Environmental toxicology
- Pharmaceutical chemistry
Experience:
Dr. Mañay is a full Professor (Senior lecturer) of Toxicology, Faculty of Chemistry, at theUniversity of the Republic of Uruguay (UdelaR). His areas of interest include. environmental, analytical, forensic, regulatory.
Additionally, Dr. Mañay has the following experience:
- Director of the Toxicology Laboratory CEQUIMTOX (Specialized in Chemical Toxicology Centre)
- Research in Chemistry and Geosciences and National Agency for Research and Innovation (ANII) in Uruguay
- Leads the analytical toxicology research group, research projects and advisory services in laboratory analysis
- Research on environmental pollutants impacts on health as toxic metals and metalloids developing analytical methods for exposure biomarkers and population biomonitoring in surveillance projects
- Toxicological research on environmental and analytical toxicology, toxic metals (methalloids) exposure, biological monitoring and health impacts in vulnerable Uruguayan populations. Research in Medical Geology and metal´s biomarkers
Recommended by Scientific/Professional
Society or General Public
Society or General Public
No
Academic and Professional Credentials
- MD
- MPH
- MS
- ScD
Current Position Title
Visiting ScholarAffiliate Professor (beginning December, 2017)
Organizational Affiliation(s)
Visiting Scholar at the University of Washington, Seattle, Washington, United States of America, Department of Occupational and Environmental Health Sciences, University of Washington School of Public Health, Seattle, WA (Current)
Dr. Hu is on sabbatical/administrative leave from the University of Toronto from July 1, 2017, to June 30, 2018. His primary position is Dean of the Dalla Lana School of Public Health at the University of Toronto, Toronto, Ontario, Canada.
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
Board certified in internal medicine and in occupational medicine.
Experience:
Founding Dean of the Dalla Lana School of Public Health at the University of Toronto, Toronto, Ontario, Canada.
His major research interests are:
- Environmental and molecular epidemiologic research on heavy metals
- Potential endocrine disruptors, other neurotoxicants, carcinogens
- Gene-environment interactions, epigenetic dysregulation
- Fetal/early life exposures and long-term effects
- Aging-environment interactions
- Environmental health, health inequities, health disparities, and human rights
- Health and the global environment
- “Big Data” for population health
- Environmental sensitivities/Multiple chemical sensitivities
Recommended by Scientific/Professional
Society or General Public
Society or General Public
No
Academic and Professional Credentials
B.Sc.MSc.
Current Position Title
Senior Scientist/Founder
Organizational Affiliation(s)
Equilibrium Environmental Inc., Calgary, AB, Canada
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
Toxicology and biochemistry
Experience:
- Toxicology
- Risk assessment
- Modelling
- Analytical techniques
- Risk management and remediation plan development
- Remediation innovation
- Hydrocarbons, salts and metalloids at upstream, midstream, and downstream oil and gas facilities
- Metals at nuclear weapon processing facilities
- Chlorinated organic compounds at pulp and paper facilities as well as former Alberta Environment Help End Landfill Pollution projects
- Chemical blends at chemical manufacturing plants
- Chemical warfare agents including chlorinated organics at Canadian test sites
- Chlorinated solvents at dry cleaner facilities
- Organic compounds at wood treatment facilities
- Organic and inorganic parameters associated with sewage processing infrastructure
Recommended by Scientific/Professional
Society or General Public
Society or General Public
No
Content Source:
Agency for Toxic Substances and Disease Registry