Hexachlorobutadiene

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of hexachlorobutadiene.

Details

Title: Toxicological Profile for Hexachlorobutadiene

Subject of Planned Report: Environmental Protection Agency has determined that hexachlorobutadiene is a possible human carcinogen. Kidney, brain, and liver damage were also seen in rabbits after skin contact. Ingestion of hexachlorobutadiene damaged the kidneys of rats and mice and the liver of rats. Studies in mice showed that brief exposure to high concentrations of hexachlorobutadiene irritate the nose. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): June July 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft will be made available for public comment in 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
PhDMSc
Current Position Title
Director, UCLA Industrial Hygiene Program
Organizational Affiliation(s)
Department of Environmental Health Sciences, Fielding School of Public Health, UCLA
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Physical chemistry
  • Chemical engineering
  • Industrial hygiene
Experience:
  • Professor, Step V, Department of Environmental Health Sciences, School of Public Health, UCLA Center for Occupational and Environmental Health, University of California at Los Angeles
  • Distinguished Professor, National Taiwan University, School of Public Health, Institute of Environmental Health
  • Director, UCLA Industrial Hygiene Program, Department of Environmental Health Sciences, Fielding School of Public Health.

Research areas of interest:
  • Detection and quantitative analysis of organic and inorganic pollutants and carcinogens in industrial and agricultural industries, and in the environment at the ng and pg level
  • Development of sensitive personal monitoring methods in industry, and workplace protection factors
  • Direct reading instruments, and direct-indicating sensors
  • Detection and quantitation of toxins in biological tissues which cause cancer or produce unwanted biological effects
  • Liquid chromatography-mass spectroscopy
  • Gas chromatography-mass spectroscopy; Developmental analytical chemistry dealing with organic, inorganic and organometallic species in-vivo and in-vitro
  • Photodecomposition and photosensitization
  • Chemiluminescent and bioluminescent analysis
  • Multielemental analyses and receptor analyses
  • Biological monitoring -screening and specific tests
  • Hazardous Waste -field and laboratory methods
  • Inductively coupled plasma-mass spectrometry and atomic emission spectroscopy
  • Organometallic biological compounds.
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor Emeritus of Pharmacology and Toxicology
Organizational Affiliation(s)
College of Pharmacy, University of Georgia
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
Pharmacology and toxicology

Experience:
Extensive experience as a peer reviewer for CDC, ATSDR, NIOSH, and EPA.

Research interests:
Questions which impact toxicity risk assessments and experimental research on the use of physiologically-based pharmacokinetic (PBPK) models to predict the administered dose/exposure level anticipated to produce the effect in humans.
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials

PhDMS
Current Position Title
Associate Professor
Organizational Affiliation(s)
Institute of Environmental Engineering, National Sun Yet-sen University
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
Civil and environmental engineering

Experience:
  • Associate director, Aerosol Science Research Center, National Sun Yat-sen University, Kaohsiung, Taiwan
  • Director of Environmental Protection and Safety, Environmental Protection and Safety Center, National Sun Yat-sen University, Kaohsiung, Taiwan, Associate Editor, Journal of Ecology & Natural Resources
  • Associate Member (A.M.), American Society of Civil Engineers
  • Member, American Chemical Society.
  • Engineer-In-Training (EIT)
  • Board for Professional Engineers and Land Surveyors, California, Certificate No. EIT 128709
Recommended by Scientific/Professional
Society or General Public
No

Resources

Additional elements to be added to the public posting as they become available:

Peer review Charge for Hexachlorobutadiene Toxicological Profile
The peer review charge and post-public draft of hexachlorobutadiene.
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Content Source:
Agency for Toxic Substances and Disease Registry