At a glance
Details
Title: Toxicological Profile for Ethyl Benzene
Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on these hazardous substances most commonly found at hazardous waste sites supports public health assessment efforts.
Type of Dissemination: ISI
Timing of Review (including deferrals): April 2010
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile was made available on October 23, 2007. The draft was available for a 90-day public comment period.
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3 or fewer
Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
Charge to Peer Reviewers: DTEM Charge to Peer Reviewers
Reviewers
- A.B., Chemistry, Hamilton College
- Ph.D., Anatomy and Teratology, Medical College of Virginia, Virginia Commonwealth University
- Fellow, Academy of Toxicological Sciences (1999)
- Fellow, American College of Forensic Examiners (1998)
- Diplomate, American Board of Forensic Examiners (1995)
- Senior Fellow
- Senior Principal Scientist for Health Science, Toxicology, and Risk Assessment
- Director of the Biomedical Research Institute, Mitretek Systems Center for Science and Technology
- Academy of Toxicological Sciences
- American Association of Anatomists
- American College of Forensic Examiners
- American Society for Cell Biology
- American Society for Reproductive Medicine (formerly American Fertility Society)
- Federation of American Societies of Experimental Biology
- International Society for the Study of Xenobiotics
- Microscopy Society of America
- Mid Atlantic Reproduction and Teratology Association (MARTA)
- Sigma Xi Society for Risk Analysis
- United States-Israel Binational Science Foundation
- Environmental Protection Agency’s Cooperative Agreements Program,
- National Institute of Occupational Safety and Health
- National Institute of Alcoholism & Alcohol Abuse
- National Foundation/March of Dimes
- National Institutes of Health
- National Institute of Environmental Health Sciences
- Pharmacology
- Human Embryology and Development 2
- Safety and Occupational Health
- Neuroscience and Behavior
Society or General Public
Dr. DeSesso's experience continued
Among his projects as Senior Scientist at Mitretek, Dr. DeSesso has headed:
- The assessment of the state of the science regarding interpretation of neural tube defects observed in safety tests.
- Preparation of a new risk assessment concerning the developmental toxicity potential of environmental exposure to inorganic arsenic.
- The assessment of the use of bioavailability data in non-cancer risk assessment.
In addition to this work for government and private sector clients, Dr. DeSesso has published numerous scientific articles in peer-reviewed journals, book chapters, and presentations to scientific meetings. He currently holds faculty appointments at three medical colleges and universities.
Dr. DeSesso has served as a committee member or committee chairman in the Society of Toxicology, the American Society of Testing Materials, and the Teratology Society. He served as an officer of both the Teratology Society (including treasurer, vice-president, president). He also served as the president of the Mid Atlantic Reproduction and Teratology Association (MARTA). He has been the Chairman of the scientific program committees for two national meetings of the Teratology Society including, one meeting with the International Federation of Teratology Societies.
- Member, TLV® Chemical Substances Committee of the American Congress of Governmental Industrial Hygienists (2005)
- Member, Committee on Toxicology of the National Research Council
- Fellow of the Academy of Toxicological Sciences
- Senior Scientist and Department Manager of the Operational Toxicology Branch at Ge0-Centers (Wright-Patterson AFB)
- Director of Research and Deputy Director of the Toxicology Division at Armstrong Laboratory (Wright-Patterson AFB)
- Chief of Life Sciences and Human Systems at the European Office of Aerospace Research & Development under the Air Force Office of Scientific Research, in New York.
Society or General Public
Society or General Public
Dr. Salmon's experience continued
Dr. Salmon leads the group of toxicologists in OEHHA responsible for public health risk assessments of Toxic Air Contaminants (TACs) under the State of California's Air Toxics programs. This includes development of risk assessments for the TACs, which are used by the California Air Resources Board for their Air Toxics Control Measures. The group also provides the methodological guidelines and health protective standards for the Hot Spots program. These guidelines are used by local Air Quality Management Districts in regulating stationary sources of TACs and other air pollutants.
Dr. Salmon's group is currently evaluating all of the Air Toxics public health standards to determine whether these are protective of the health of children and other potentially sensitive sub-populations. This is in response to California's recent Children's Environmental Health Protection legislation ("SB25").
Earlier research activities included a range of biochemical and toxicological studies (including inhalation exposure studies) undertaken at academic and commercial laboratories. Interests included:
- Chemical carcinogenesis
- Pharmacokinetics and metabolism (including biophysical and cell culture studies of cytochrome P-450
- Metabolism studies in vivo and in vitro of pesticides and volatile halocarbons)
- Neurobehavioral studies of hydrocarbon solvents.
He also studied toxic effects of methyl isocyanate, working with epidemiologists who were examining the after-effects of the Bhopal disaster.