Endrin

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of endrin.

Details

Title: Toxicological Profile for Endrin

Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicologic, epidemiologic, and adverse health effects for the substance described. It also summarizes environmental fate and transport mechanisms and the potential for human exposure.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste supports public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft of this profile was made available for public comment June 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: Toxicology, Epidemiology, Environmental Fate & Transport, Environmental Health

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
PhD (Toxicology University of Michigan) 2001
Postdoctoral Fellowship (Pharmacology/Pharmaceutical Sciences University of Colorado) 2004
Current Position Title
  • Associate Professor of Medicinal and Natural Products Chemistry (with tenure)
  • Division Chair of Medicinal and Natural Products Chemistry
  • Co-Director, Oxidative Stress and Metabolism Core
  • Environmental Health Sciences Research Center, January 2016 – Present
Organizational Affiliation(s)
The University of Iowa
College of Pharmacy,
Division of Medicinal and Natural Products Chemistry
Iowa City, IA 52242
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Toxicology
  • Neurotoxicology
  • Toxic neurotransmitter metabolites in aged and diabetic human myocardium
Experience:
  • Pesticide-Mediated Generation of a Toxic Neurotransmitter Metabolite
  • Contribution of Glial Cells to Neurotoxicity and Neurodegeneration
Dr. Doorn’s work involves examining the role of reactive intermediates in toxicity and disease. Specifically, his mechanistic, hypothesis-driven research focuses on the potential role of protein modification by a reactive metabolite of dopamine metabolism in neurotoxicity and neurodegenerative disease, i.e. Parkinson’s disease. Dopamine (DA) is an important neurotransmitter that is metabolized by monoamine oxidase to 3,4-dihydroxyphenylacetaldehyde (DOPAL), an intermediate shown to be reactive toward proteins and toxic to dopaminergic cells.
Publications

Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
  • Ph.D.
  • Fellow, Academy of Toxicological Sciences
  • Fellow, International Academy of Toxicological Pathology
Current Position Title
  • Professor, Environmental Health
  • Professor, School of Public and Environmental Affairs
  • Laboratory of Investigative Toxicology and Pathology
Organizational Affiliation(s)
Indiana University
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Pathology
  • Toxicology
  • Carcinogenesis
  • Environmental health
Experience:
  • 2008 – present Editorial Board Toxicology
  • 2005 – 2008 Editor- in-Chief, Toxicologic Patholog
  • Publications
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
  • PhD (Medicinal Chemistry, Indian Institute of Chemical Biology, Calcutta, 1982)
  • MACN
  • CNS
  • MAIChE
Current Position Title
  • Chief Scientific Officer; Cepham Research Center. San Francisco Bay Area, Industry Pharmaceuticals
  • Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX
Organizational Affiliation(s)
  • Cepham Research Center
  • University of Houston College of Pharmacy
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Medicinal chemistry
  • Pharmacology
  • Metabolism (energy)
  • Effects of natural products on metabolism
  • Nutraceutical and functional foods
Experience:
Dr. Bagchi is the Immediate Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL.He is a member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. Dr. Bagchi is also one of the Associate Editors of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research. He is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, The Original Internist, and others.
Publications
Recommended by Scientific/Professional Society or General Public
No

Resources

Guidelines for Peer Review of Toxicological Profiles
Guidelines for peer reviewers of toxicological profiles to enable ATSDR to address your comments.
CDC/ATSDR’s Response to Reviewers’ Comments for Toxicological Profile for Endrin
Download
Download
The ISI/HISA Dissemination Itself
Print
Content Source:
Agency for Toxic Substances and Disease Registry