Chlorobenzene

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of chlorobenzene.

Details

Title: Toxicological Profile for Chlorobenzene

Subject of Planned Report: The ATSDR toxicological profile reviews the toxicologic, epidemiologic, and adverse health effects for the substance being described. It also summarizes environmental fate and transport mechanisms and the potential for human exposure.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on these hazardous substances supports public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): individual

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft will be made available for public comment in 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 4

Primary Disciplines or Expertise: Toxicology, Epidemiology, Environmental Fate & Transport, Environmental Health

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
PhD
Current Position Title
Professor
Organizational Affiliation(s)
Department of Biochemistry & Molecular Biology, Department of Pathology, University of Texas Medical Branch
Areas of Expertise, Discipline, Relevant Experiences
  • Molecular toxicology and systems biology
  • Biomarker signatures and metabolomics
  • Chemical-mediated liver injury and chemical-mediated autoimmunity.
  • He has over 120 publications and 5 book chapters.
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
  • Director of Graduate Studies
  • Environmental and Occupational Health
Organizational Affiliation(s)
Indiana University
Department of Environmental Health
School of Public Health
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Pharmacology
  • Toxicology
  • Occupational health and disease
  • Toxicity studies
Experience:
Dr. Lisa M. Kamendulis is Core Director, Oxidative Stress and Environmental Analysis Core at Indiana University Department of Environmental Health. After completing her undergraduate degree in Biology from the University of Massachusetts at Amherst, Dr. Kamendulis received her Ph.D. Toxicology from the University of New Mexico in 1994. There, she studied mechanisms of hepatotoxicity, specifically focusing on the induction of apoptosis. Her research focused on examining mechanisms by which environmental agents and therapeutic drugs elicit liver cancer, both in vivo and in vitro rodent models. She then examined the role of oxidative stress in modulating growth regulatory signaling networks and gene expression elicited by nongenotoxic carcinogens. She has published over 60 peer-reviewed manuscripts, and book chapters in the areas of Toxicology and chemical carcinogenesis.
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Research Professor
Organizational Affiliation(s)
The George Perkins Marsh InstituteClark University
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Pharmacokinetics
  • Risk assessment
  • Pharmacodynamics
  • Toxicology
  • Toxicity
  • Pharmacokinetic modeling
  • Pharmacogenetics
  • Toxicokinetics
  • PKPD modeling
  • Human health
Experience:
Bridge the gap between experimental scientists and statistical researchers by representing the causal mechanisms that are likely to lead to biological damage of policy interest. The principal foci of his past work are the use of various biomarkers and physiologically-based pharmacokinetic models to:

  • Improve risk assessment for carcinogens.
  • Quantitative treatment of inter-individual variability in susceptibility for a wide variety of non-cancer effects.
  • The use of Monte Carlo simulations to represent the combined effects of multiple sources of uncertainty and variability.
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
  • MS
  • Ph.D
Current Position Title
Professor Emeritus, Board Certified Toxicologist
Organizational Affiliation(s)
University of Missouri
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Toxicology
  • Medical sciences
  • Infectious disease
  • Environmental health
  • Microbiology
  • Veterinary sciences
Experience: Dr. Brown has held appointments as:

  • Professor Emeritus, University of Missouri, Columbia, MO
  • Dalton Cardiovascular Research Center, the Graduate School
  • Department of Molecular Microbiology and Immunology, School of Medicine
  • Dept. of Biomedical Sciences & Adjunct Professor of Pathology, College of Veterinary Medicine.
He has more than 100 publications and has been a peer reviewer for several federal agencies (NIH, NIEHS, CDC, ATSDR, Superfund and others).
Recommended by Scientific/Professional Society or General Public
No

Resources

Guidelines for Peer Review of Toxicological Profiles
Guidelines for peer reviewers of toxicological profiles to enable ATSDR to address your comments.
CDC/ATSDR’s Response to Reviewers’ Comments for Toxicological Profile for Chlorobenzene
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Content Source:
Agency for Toxic Substances and Disease Registry