September 2, 2024

2-Butanone

Toxicological Profile

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of 2-butanone.

Details

Title: Toxicological Profile for 2-Butanone

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on these hazardous substances supports public health assessment efforts at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): May 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft was made available for public comment June 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials

PhD

Current Position Title

Professor

Organizational Affiliation(s)

Department of Biochemistry & Molecular Biology, Department of Pathology, University of Texas Medical Branch

Areas of Expertise, Discipline, Relevant Experiences

Expertise / Discipline:

Molecular toxicology and systems biology
Biomarker signatures and metabolomics
Chemical-mediated liver injury and chemical-mediated autoimmunity

Experience:

He has over 120 publications and 5 book chapters. He also received many honors and awards.

Recommended by Scientific/Professional Society or General Public

Academic and Professional Credentials

PhD

Current Position Title

Professor of Biochemistry, Tadashi Inagami Chair in Biochemistry

Organizational Affiliation(s)

Department of Biochemistry, The Vanderbilt University School of Medicine

Areas of Expertise, Discipline, Relevant Experiences

Expertise / Discipline:

Biochemistry
Drug metabolism
Mass spectrometry
Mutation
Pharmacology
Polymorphism
Spectroscopy
Toxicology
Chemistry and enzymology of bioactivation and detoxication of foreign compounds

Experience:

Mechanisms of activation and detoxication of chemical carcinogens and toxicants
Characterization of enzymes involved in these processes
Metabolism of carcinogens and drugs by cytochrome P450 enzymes
The bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA.

Recommended by Scientific/Professional Society or General Public

Academic and Professional Credentials

PhD

Current Position Title

Research Professor

Organizational Affiliation(s)

The George Perkins Marsh InstituteClark University

Areas of Expertise, Discipline, Relevant Experiences

Expertise / Discipline:

Pharmacokinetics
Risk assessment
Pharmacodynamics
Toxicology, toxicity
Pharmacokinetic modeling
Pharmacogenetics
Toxicokinetics
PKPD modeling
Human health

Experience:

Dr. Hattis bridges the gap between experimental scientists and statistical researchers by representing the causal mechanisms that are likely to lead to biological damage of policy interest. The principal foci of his past work are the use of various biomarkers and physiologically-based pharmacokinetic models to improve risk assessment for carcinogens; quantitative treatment of inter-individual variability in susceptibility for a wide variety of non-cancer effects; and the use of Monte Carlo simulations to represent the combined effects of multiple sources of uncertainty and variability.

Recommended by Scientific/Professional Society or General Public