1,1,2-Trichloroethane

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of 1,1,2-trichloroethane.

Details

Title: Toxicological Profile for 1,1,2-Trichloroethane

Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicological and epidemiological literature and helps to identify adverse health effects of the substance being described. It also summarizes environmental fate and transport mechanisms and the potential for human exposure. Sources of information include unpublished studies which also require simultaneous peer review.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): individual

Type of Review (panel, individual or alternative procedure): individual

Opportunities for Public Comment (how and when): A draft of this profile will be made available for public comment in 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: Toxicology, Toxicological Pathology, Pharmacokinetic Modeling, Risk Assessment, Environmental Health

[Note that this edition is only a partial update of the previous Toxicological Profile. Updates focused on health effects in Chapters 2, 3, and 7.]

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
  • DVM
  • PhD
  • DABT
  • DABVT
  • ATS
Current Position Title
Professor, Toxicology
Organizational Affiliation(s)
North Carolina State University, Raleigh, NC
Areas of Expertise, Discipline, Relevant Experiences
  • Veterinary Pathologist
  • Toxicological Pathologist
  • Respiratory Toxicology
  • Neurobiology
  • Pharmacology
  • Toxicology
  • Pharmacokinetics
  • Risk Assessment
Dr. Dorman is an expert on systematic reviews of animal toxicity studies, upper respiratory tract exposures. and effects including damage to olfactory epithelium.


Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor emeritus, Interdisciplinary Toxicology Program, Pharmaceutical & Biomedical Sciences, College of Pharmacy
Organizational Affiliation(s)
University of Georgia, Athens, GA

Areas of Expertise, Discipline, Relevant Experiences
  • Toxicology
  • Pharmacokinetics including PBPK modeling
  • Toxicological expertise on similar small, chlorinated VOCs
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
  • M.D.
  • Ph.D.
Current Position Title
  • Professor and Chair, Department of Veterinary Integrative Biosciences. College of Vet Medicine & Biomedical Sciences
  • Director, Superfund Research Center
Organizational Affiliation(s)
Texas A&M University; College Station, TX
Areas of Expertise, Discipline, Relevant Experiences
  • Toxicology
  • Hepatic toxicity
  • Risk Assessment
  • Health effects of small, chlorinated VOCs
  • Carcinogenesis
Recommended by Scientific/Professional
Society or General Public
No

Resources

Additional elements to be added to the public posting as they become available:

Guidelines for Peer Review of Toxicological Profiles
Guidelines for peer reviewers of toxicological profiles to enable ATSDR to address your comments.
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Content Source:
Agency for Toxic Substances and Disease Registry