1,2-Dichloropropane

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of 1,2-Dichloropropane.

Details

Title: Toxicological Profile for 1,2-Dichloropropane

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances commonly found on hazardous waste sites supports public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public Comment (how and when): A draft will be made available for public comment in 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
DPH
Current Position Title
Senior Scientist Emeritus
Organizational Affiliation(s)
Lovelace Respiratory Research Institute
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Toxicology
  • Biochemistry
  • Chemistry
Experience:
Dr. Michaels has chaired the State of Maine Scientific Advisory Panel and the Certification Review Board of the Academy of Board Certified Environmental Professionals (ABCEP). He earned his PhD at SUNY at Stony Brook in 1979. In 2004 he was awarded ABCEP’s Kramer Medal for his contributions. He has also been:

  • Secretary of the NFPA Comm. on Classification and Properties of Hazardous Chemicals
  • Board Member of the National Association of Environmental Professionals
  • Member of the Editorial Advisory Boards of science journals


Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Associate Professor, Director of Graduate Studies
Organizational Affiliation(s)
School of Public and Environmental Affairs, Indiana University
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Pharmacology
  • Toxicology
  • Occupational health and disease
  • Toxicity studies
Experience:
Dr. Lisa M. Kamendulis is Core Director, Oxidative Stress and Environmental Analysis Core at Indiana University Department of Environmental Health. After completing her undergraduate degree in Biology from the University of Massachusetts at Amherst, Dr. Kamendulis received her Ph.D. Toxicology from the University of New Mexico in 1994. There, she studied mechanisms of hepatotoxicity, specifically focusing on the induction of apoptosis. Her research focused on examining mechanisms by which environmental agents and therapeutic drugs elicit liver cancer, both in vivo and in vitro rodent models. This was performed to examine the role of oxidative stress in modulating growth regulatory signaling networks and gene expression elicited by nongenotoxic carcinogens. Dr. Kamendulis has published over 60 peer-reviewed manuscripts, and book chapters in the areas of Toxicology and chemical carcinogenesis.
Recommended by Scientific/Professional Society or General Public
No

Academic and Professional Credentials
  • MS
  • Ph.D.
Current Position Title
Professor Emeritus, Board Certified Toxicologist
Organizational Affiliation(s)
University of Missouri
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Toxicology
  • Medical sciences
  • Infectious disease
  • Environmental health
  • Microbiology
  • Veterinary sciences
Experience:
Dr. Brown has held appointments as:
  • Professor Emeritus, University of Missouri, Columbia, MO
  • Dalton Cardiovascular Research Center, the Graduate School
  • Department of Molecular Microbiology and Immunology, School of Medicine
  • Dept. of Biomedical Sciences & Adjunct Professor of Pathology, College of Veterinary Medicine.
Dr. Brown has more than 100 publications and has been a peer reviewer for several federal agencies (NIH, NIEHS, CDC, ATSDR, Superfund and others).
Recommended by Scientific/Professional Society or General Public
No

Resources

Additional elements to be added to the public posting as they become available:

Peer Review Charge for 1,2-Dichloropropane
The peer review charge and post-public draft of 1,2-dichloropropane.
Print
Content Source:
Agency for Toxic Substances and Disease Registry