1,2,3-Trichloropropane

Toxicological Profile

At a glance

NCEH/ATSDR makes peer review information available to demonstrate efforts to utilize transparent and independent peer review, appropriate research methods, and the highest level of data quality. This ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects of 1,2,3-trichloropropane.

Details

Title: Toxicological Profile for 1,2,3-Trichloropropane

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data. Data on hazardous substances most commonly found at hazardous waste sites support public health assessment efforts.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for Public Comment (how and when): A draft of this profile was made available for public comment June 2019.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Reviewers

Academic and Professional Credentials
PhD
Current Position Title
Professor and Director of EOHSI, Rutgers
Organizational Affiliation(s)
Rutgers School of Public Health
Department of Environmental & Occupational Health Sciences Institute (EOHSI)
and Director of the National Institute of
Environmental Health Sciences (NIEHS)
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Toxicogenomics and functional genomics
  • Carcinogenesis
  • Molecular and cellular biology
  • Toxicology
  • Oncogene activation
  • Mechanisms of signal transduction
  • Genetic linkage analysis
His studies in the area of toxicogenomics include the development and application of standards for DNA microarray experiments. Additionally, it includes phenotypic anchoring of response of human cells, model organisms (yeast) and target organs (rodents) to toxicants. This research provides insights into dose and temporal responses, as well as mechanisms of action. Dr. Zarbl is also actively involved in technology development for functional genomics and biomarker screening.

Experience:
Dr. Zarbl serves as the Director of the NIEHS sponsored Center for Environmental Exposures and Disease. He is the Associate Director for Public Health Sciences at the Cancer Institute of New Jersey. He serves on numerous national research review and advisory panels, and editorial panels.

Dr. Zarbl is known for his work in areas of:

  • Toxicogenomics
  • Mechanisms of and genetic susceptibility to chemical carcinogenesis
  • Mechanisms of mutagenesis and toxicity
  • Technology development.
These research efforts have to date resulted in over 70 scientific papers and book chapters.
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Research Professor
Organizational Affiliation(s)
George Perkins Marsh Institute, Clark University
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Pharmacokinetics
  • Risk assessment
  • Pharmacodynamics
  • Toxicology
  • Toxicity
  • Pharmacokinetic modeling
  • Pharmacogenetics
  • Toxicokinetics
  • PKPD modeling
  • Human health

Experience:
Dr. Hattis bridges the gap between experimental scientists and statistical researchers. He does this by representing the causal mechanisms that are likely to lead to biological damage of policy interest. The principal foci of his past work are:

  • The use of various biomarkers and physiologically-based pharmacokinetic models to improve risk assessment for carcinogens.
  • Quantitative treatment of inter-individual variability in susceptibility for a wide variety of non-cancer effects.
  • The use of Monte Carlo simulations to represent the combined effects of multiple sources of uncertainty and variability.
Recommended by Scientific/Professional
Society or General Public
No

Academic and Professional Credentials
PhD
Current Position Title
Professor
Organizational Affiliation(s)
Department of Biochemistry & Molecular Biology, Department of Pathology, University of Texas Medical Branch
Areas of Expertise, Discipline, Relevant Experiences
Expertise / Discipline:
  • Molecular toxicology and systems biology
  • Biomarker signatures and metabolomics
  • Chemical-mediated liver injury and chemical-mediated autoimmunity

Experience:
  • Molecular toxicology
  • Biomarker signatures
  • Metabolomics
  • Chemical – mediated autoimmunity, chemical – mediated liver injury, systems biology
Dr. Ansari has over 120 publications and 5 book chapter and has received many honors and awards.
Recommended by Scientific/Professional
Society or General Public
No

Resources

Guidelines for Peer Review of Toxicological Profiles
Guidelines for peer reviewers of toxicological profiles to enable ATSDR to address your comments.
Peer Review Charge for 1,2,3-Trichloropropane Toxicological Profile
Review the peer review charge and post-public draft of 1,2,3-Trichloropropane.
CDC/ATSDR’s Response to Reviewers’ Comments for Toxicological Profile for 1,2,3-Trichloropropane
Download
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The ISI/HISA Dissemination Itself
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Content Source:
Agency for Toxic Substances and Disease Registry